The influence of direct laser metal sintering implants on the early stages of osseointegration in diabetic mini-pigs
Identifieur interne : 000035 ( Main/Exploration ); précédent : 000034; suivant : 000036The influence of direct laser metal sintering implants on the early stages of osseointegration in diabetic mini-pigs
Auteurs : Naiwen Tan [République populaire de Chine] ; Xiangwei Liu [République populaire de Chine] ; Yanhui Cai [République populaire de Chine] ; Sijia Zhang [République populaire de Chine] ; Bo Jian [République populaire de Chine] ; Yuchao Zhou [République populaire de Chine] ; Xiaoru Xu [République populaire de Chine] ; Shuai Ren [République populaire de Chine] ; Hongbo Wei [République populaire de Chine] ; Yingliang Song [République populaire de Chine]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2017.
Abstract
High failure rates of oral implants have been reported in diabetic patients due to the disruption of osseointegration. The aim of this study was to investigate whether direct laser metal sintering (DLMS) could improve osseointegration in diabetic animal models.
Surface characterizations were carried out on two types of implants. Cell morphology and the osteogenic-related gene expression of MG63 cells were observed under conditions of DLMS and microarc oxidation (MAO). A diabetes model in mini-pigs was established by intravenous injection of streptozotocin (150 mg/kg), and a total of 36 implants were inserted into the mandibular region. Micro-computed tomography (micro-CT) and histologic evaluations were performed 3 and 6 months after implantation.
The Ra (the average of the absolute height of all points) of MAO surface was 2.3±0.3 µm while the DLMS surface showed the Ra of 27.4±1.1 µm. The cells on DLMS implants spread out more podia than those on MAO implants through cell morphology analysis. Osteogenic-related gene expression was also dramatically increased in the DLMS group. Obvious improvement was observed in the micro-CT and Van Gieson staining analyses of DLMS implants compared with MAO at 3 months, although this difference disappeared by 6 months. DLMS implants showed a higher bone–implant contact percentage (33.2%±11.2%) at 3 months compared with MAO group (18.9%±7.3%) while similar results were showed at 6 months between DLMS group (42.8%±10.1%) and MAO group (38.3%±10.8%).
The three-dimensional environment of implant surfaces with highly porous and fully interconnected channel and pore architectures can improve cell spreading and accelerate the progress of osseointegration in diabetic mini-pigs.
Url:
DOI: 10.2147/IJN.S138615
PubMed: 28814861
PubMed Central: 5546787
Affiliations:
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for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Yuchao" sort="Zhou, Yuchao" uniqKey="Zhou Y" first="Yuchao" last="Zhou">Yuchao Zhou</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-5433">State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, 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China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Ren, Shuai" sort="Ren, Shuai" uniqKey="Ren S" first="Shuai" last="Ren">Shuai Ren</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-5433">State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, 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Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Song, Yingliang" sort="Song, Yingliang" uniqKey="Song Y" first="Yingliang" last="Song">Yingliang Song</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-5433">State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, 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Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijn-12-5433">Department of Stomatology, Hospital 463 of PLA, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, Hospital 463 of PLA, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Xiangwei" sort="Liu, Xiangwei" uniqKey="Liu X" first="Xiangwei" last="Liu">Xiangwei Liu</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-5433">State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Cai, Yanhui" sort="Cai, Yanhui" uniqKey="Cai Y" first="Yanhui" last="Cai">Yanhui Cai</name><affiliation wicri:level="1"><nlm:aff id="af4-ijn-12-5433">Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Sijia" sort="Zhang, Sijia" uniqKey="Zhang S" first="Sijia" last="Zhang">Sijia Zhang</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-5433">State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Jian, Bo" sort="Jian, Bo" uniqKey="Jian B" first="Bo" last="Jian">Bo Jian</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-5433">State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Yuchao" sort="Zhou, Yuchao" uniqKey="Zhou Y" first="Yuchao" last="Zhou">Yuchao Zhou</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-5433">State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Xiaoru" sort="Xu, Xiaoru" uniqKey="Xu X" first="Xiaoru" last="Xu">Xiaoru Xu</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-5433">State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Ren, Shuai" sort="Ren, Shuai" uniqKey="Ren S" first="Shuai" last="Ren">Shuai Ren</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-5433">State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Hongbo" sort="Wei, Hongbo" uniqKey="Wei H" first="Hongbo" last="Wei">Hongbo Wei</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-5433">State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Song, Yingliang" sort="Song, Yingliang" uniqKey="Song Y" first="Yingliang" last="Song">Yingliang Song</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-12-5433">State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-12-5433">Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Nanomedicine</title><idno type="ISSN">1176-9114</idno><idno type="eISSN">1178-2013</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>High failure rates of oral implants have been reported in diabetic patients due to the disruption of osseointegration. The aim of this study was to investigate whether direct laser metal sintering (DLMS) could improve osseointegration in diabetic animal models.</p></sec><sec><title>Methods</title><p>Surface characterizations were carried out on two types of implants. Cell morphology and the osteogenic-related gene expression of MG63 cells were observed under conditions of DLMS and microarc oxidation (MAO). A diabetes model in mini-pigs was established by intravenous injection of streptozotocin (150 mg/kg), and a total of 36 implants were inserted into the mandibular region. Micro-computed tomography (micro-CT) and histologic evaluations were performed 3 and 6 months after implantation.</p></sec><sec><title>Results</title><p>The Ra (the average of the absolute height of all points) of MAO surface was 2.3±0.3 µm while the DLMS surface showed the Ra of 27.4±1.1 µm. The cells on DLMS implants spread out more podia than those on MAO implants through cell morphology analysis. Osteogenic-related gene expression was also dramatically increased in the DLMS group. Obvious improvement was observed in the micro-CT and Van Gieson staining analyses of DLMS implants compared with MAO at 3 months, although this difference disappeared by 6 months. DLMS implants showed a higher bone–implant contact percentage (33.2%±11.2%) at 3 months compared with MAO group (18.9%±7.3%) while similar results were showed at 6 months between DLMS group (42.8%±10.1%) and MAO group (38.3%±10.8%).</p></sec><sec><title>Conclusion</title><p>The three-dimensional environment of implant surfaces with highly porous and fully interconnected channel and pore architectures can improve cell spreading and accelerate the progress of osseointegration in diabetic mini-pigs.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Branemark, Pi" uniqKey="Branemark P">PI Branemark</name></author><author><name sortKey="Adell, R" uniqKey="Adell R">R Adell</name></author><author><name sortKey="Breine, U" uniqKey="Breine U">U Breine</name></author><author><name sortKey="Hansson, Bo" uniqKey="Hansson B">BO Hansson</name></author><author><name sortKey="Lindstrom, J" uniqKey="Lindstrom J">J 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last="Liu">Xiangwei Liu</name><name sortKey="Ren, Shuai" sort="Ren, Shuai" uniqKey="Ren S" first="Shuai" last="Ren">Shuai Ren</name><name sortKey="Ren, Shuai" sort="Ren, Shuai" uniqKey="Ren S" first="Shuai" last="Ren">Shuai Ren</name><name sortKey="Song, Yingliang" sort="Song, Yingliang" uniqKey="Song Y" first="Yingliang" last="Song">Yingliang Song</name><name sortKey="Song, Yingliang" sort="Song, Yingliang" uniqKey="Song Y" first="Yingliang" last="Song">Yingliang Song</name><name sortKey="Tan, Naiwen" sort="Tan, Naiwen" uniqKey="Tan N" first="Naiwen" last="Tan">Naiwen Tan</name><name sortKey="Tan, Naiwen" sort="Tan, Naiwen" uniqKey="Tan N" first="Naiwen" last="Tan">Naiwen Tan</name><name sortKey="Wei, Hongbo" sort="Wei, Hongbo" uniqKey="Wei H" first="Hongbo" last="Wei">Hongbo Wei</name><name sortKey="Wei, Hongbo" sort="Wei, Hongbo" uniqKey="Wei H" first="Hongbo" last="Wei">Hongbo Wei</name><name sortKey="Xu, Xiaoru" sort="Xu, Xiaoru" uniqKey="Xu X" first="Xiaoru" last="Xu">Xiaoru Xu</name><name sortKey="Xu, Xiaoru" sort="Xu, Xiaoru" uniqKey="Xu X" first="Xiaoru" last="Xu">Xiaoru Xu</name><name sortKey="Zhang, Sijia" sort="Zhang, Sijia" uniqKey="Zhang S" first="Sijia" last="Zhang">Sijia Zhang</name><name sortKey="Zhang, Sijia" sort="Zhang, Sijia" uniqKey="Zhang S" first="Sijia" last="Zhang">Sijia Zhang</name><name sortKey="Zhou, Yuchao" sort="Zhou, Yuchao" uniqKey="Zhou Y" first="Yuchao" last="Zhou">Yuchao Zhou</name><name sortKey="Zhou, Yuchao" sort="Zhou, Yuchao" uniqKey="Zhou Y" first="Yuchao" last="Zhou">Yuchao Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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